Contribution from Protein Conformation Transition
Mechanisms and Free Energies of Catalysis
Dynamics and Tunneling in Catalysis
Illustrative Examples
Protein Tyrosine Phosphatases
Cathepsin K
Phosphotriesterase (PTE)
Alanine Racemase
Carbon Acidity
Mechanism
Enolase
Haloalkane Dehalogenase
Mechanism and Kinetic Isotope Effect
Dynamics and Mechanism
Decarboxylases
4-Oxalocrotonate Tautomerase
Hairpin Ribozyme
Nitroalkane Oxidase
Dopa Decarboxylase
Acutolysin
Aristolochene Synthase
Dihydrofolate Reductase (DHFR)
Temperature dependence KIE
Reaction Path and Mechanism
Nature of Transition State
KIE in Hyperthermophilic DHFR
Squalene Cyclase
4-Chlorobenzoyl-CoA dehalogenase
Acyl-CoA Dehydrogenase
Free Energy Surface, Reaction Paths, and KIE
Potential of Mean Force and Effects of Mutations
Liver alcohol dehydrogenase
Quantum Dynamics of Hydride Transfer
Canonical Variational Theory, Quantum Mechanical Tunneling Dynamics
Xylose Isomerase
Carbonic Anhydrase
HIV-1 Protease