Protein Primer Volume II Topics as of 6-15-03

Compensation theory

Benzinger’s discovery and failures in applications of thermodynamics

Mean-field potential theory and compensation behavior

Linear-response theory

Linear free energy theory-

Free-energy complimentarity

Two states of water –implications for classical chemistry

Two states of water and protein hydration

Excluded volume

Helfrich effect in protein-protein association

Solubility (Anson globulin versus Neurath albumin)

Prions and other knot perturbations

Archae –extremophiles-spider silk and amyloid placks

Immunoglobulins

Potential of solvent control of and by protein solutes as by bovine serum albumin

Ligation and protein activity from solvent point of view

Generalize free-energy flow and switching

Completing the knot and tight binding by proteins

Specificity in substrate and inhibitor selection-dependence on residue choices and dynamical basis..

Enzyme kinetics for nutcracker mechanisms

Why proteins are large