Welcome to the website of the Pomerantz Lab at UMN!
The Pomerantz lab is a chemical biology group at the University of Minnesota. Our interdisciplinary research encompasses a wide range of topics including organic synthesis, bioanalytical chemistry, biochemistry and molecular biology for studying the function of transcription factors involved in disease. Our primary goal is to discover small molecules which we can synthesize in the laboratory to modulate the function of transcription factor-protein interactions, with the ultimate goal of developing new chemical probes for understanding the biology of these proteins.
April 14th, 2017 - Congratulations to Clifford on the acceptance of his paper to the Journal of Chemical Education on protein quantification using smartphone colorimetry. The DOI and link to the paper will be updated when available.
March 30th, 2017 - Congratulations to Dr. Andrew Urick for successfully defending his dissertation research "Development of Protein-Observed Fluorine Nuclear Magnetic Resonance Spectroscopy as a Ligand Discovery Technique" Andrew will be leaving for Massachusetts to begin working as a senior scientist at Abbvie.
In addition to a very productive dissertation his significant service contributions to the biological chemistry community in the department through codeveloping the chemical biology bootcamp are highly appreciated. Best of luck Andrew!
March 28th, 2017 - Congratulations to Steve and Sofi on the acceptance of their paper into Angewandte Chemie. The DOI and link to the paper will be updated when available. Great work!
March 17th, 2017 - Did you miss the fifth annual International Chemical Biology Society (ICBS) meeting in Madison? Do you want to read up on some of the highlights? Check out the Meeting Proceedings paper that was just published online through ACS Chemical Biology and co-authored by Professor Pomerantz, Peter Ycas, two members from the Georg lab in Medicinal Chemistry, and two researchers from Japan.
February 14th, 2017 - Professor Pomerantz has been featured in a profile on the American Association for Cancer Research website. Read more here
February 9th, 2017 - Congratulations to Jorden for passing her oral exam and earning Ph.D. candidate status!
February 1st, 2017 - Congratulations to Andrew who just accepted a position as a Senior Scientist at AbbVie Bioresearch Center in Worcester, Massachusetts! He will be starting this April and will be the first Pomerantz lab member to graduate with his Ph.D.
January 27th, 2017 - Congratulations to Amani for passing his oral exam and earning Ph.D candidate status!
January 13th, 2017 - Congratulations to Dr. Laura Hawk on her new job as an Assistant Professor of Chemistry at Grand Valley State University in Michigan starting this August!
December 27th, 2016 - The Pomerantz lab has two exciting pieces of news to share. The first is that Dr. Dan Erlanson from Carmot Therapeutics has included both Keith's J. Med. Chem. review and our Nature Protocols paper in a recent post on the Practical Fragments blog. The second, and even more exciting piece of news is that we have received word that our NIGMS R01 grant on studying the role of BPTF effector domains in cancer has been accepted.
September 28th, 2016 - Congratulations to Prof. Pomerantz for receiving the ICBS Young Chemical Biologist Award! He will be delivering a podium presentation during the Rising Stars of Chemical Biology session at the ICBS conference in Madison this October.
March 3rd, 2016 - Congratulations to Peter passing his oral exam and obtaining Ph.D. candidacy!
February 24th, 2016 - Congratulations to Prof. Pomerantz for being named one of 24 2016 Cottrell Scholars by the Research Corporation for Science Advancement! The proposal for this grant is titled "Fluorinated Peptides and Proteins for 19F MRI and Integrated Research Experiences in an Organic Chemistry Lab Course. Read more here on the departmental page.
January 25th, 2016 - The Pomerantz lab is happy to welcome Anand Divakaran into the group as a first year student from Med Chem! Anand will be working on both the stabilized peptide project as well as a new PrOF project.
January 15th, 2016 - Congratulationsi to Prof. Pomerantz for receiving one of the 2016-2018 McKnight Land-Grant awards, one of the top honors for assistant professors at the University of Minnesota!
January 7th, 2016 - Keith's J. Med. Chem. review on PrOF NMR has been recommended in F1000Prime as being a paper of special significance. Congratulations and many thanks to Dr. Arora for the recommendation!
December 4th, 2015 - Our paper describing Protein Observed Fluorine (PrOF) NMR has been accepted to Nature Protocols. Congratulations to everyone who contributed!
November 24th, 2015 - The Pomerantz lab welcomes two new first year graduate students, Jorden Johnson and Amani Lee. Jorden will be working on the bromodomain projects while Amani will be coadvised by Christy Haynes and will work on a collaborative project between the two labs.
October 29th, 2015 - Prof. Pomerantz is interviewed on an ACS Chemical Biology podcast, discussing the lab's recent paper on the discovery of small molecule AU1 for the inhibition of the bromodomain of the protein BPTF. Check out the podcast on the ACS website or here. Prof. Pomerantz starts around the 5:30 mark.
Fall 2015 - Welcome to incoming class of chemistry and medicinal chemistry graduate students! For those of you interested in joining the Pomerantz lab, feel free to contact any of us. Group member information can be found following the "Members" link on the side. Group meetings are typically Thursdays, 4 pm, in Kolthoff 283. Contact Prof. Pomerantz for details and/or check out the group meeting schedule.
Fall 2015 - The Pomerantz lab welcomes several new members to the lab this fall! Welcome to Medicinal Chemistry rotation student Dmitri Konorev, postdoctoral researcher Siva Talluri, undergraduate students Sofia Maltseva, Andrew Koval, and Rachel Staebel, and visiting research student Huarui.
September 3rd, 2015 - Congratulations to Keith on a successful masters' defense!
Summer 2015 - The Pomerantz lab welcomes Emily Sherman, a LANDO Research student visiting from Ithaca College, Anand Divakaran, a rotation student from the Department of Medicinal Chemistry, Alex Ayoub, a Heisig Summer Research fellow , and Amani Lee, a DOVE fellowship recipient. Emily will be working with Steve on a synthetic project, Anand will be working with Neeraj in expressing some new protein constructs, Alex will be working with Laura developing a new biochemical assay for proteins of interest, and Amani will be working on a collaborative project between the Pomerantz and Haynes labs.
May 6th, 2015 - Collaborative bromodomain project with the Hall lab finally submitted. Fingers crossed for AU1.
April 2015 - Pomerantz lab receives an American Heart Association grant to study the role of BPTF in cardiovascular disease
April 28th, 2015 - Congratulations to undergraduate lab member Ed Koleski for receiving the Senior Award from the Department of Chemistry.
February 23rd 2015 - Congratulations to Steve on passing his oral exam and obtaining Ph.D. Candidate status!
February 18th 2015 - PrOF NMR gets blogged on Practical Fragments! This blog, which is run by Dan Erlanson and Teddy Zartler, is well regarded in its evaluation of a wide variety of topics as they related to fragment-based drug
January 6th-14th 2015 - The 2nd installment of the Chemical Biology bootcamp has started! Eight students from four different research labs particpated in a 6 day chemical biology laboratory series. Special thanks to TA's Andrew Urick, Dr. Laura Hawk, Clifford Gee, and Steve Kirberger for their helpful assistance
Jan 5th, 2015 - The Pomerantz Lab is very grateful to the Garber family and relatives for their generous support of our research.
December 15th, 2014 - 3rd year graduate student Clifford Gee and undergraduate student Ed Koleski's PrOF NMR screening paper is accepted to Angewandte Chemie.
Fall 2014 - The Pomerantz lab welcomes new undergraduate students Makenna Habegger who will be working with graduate student Brie Perell on stabilized peptides and Ed Koleski who will be working with graduate student Clifford Gee on developing small molecule ligands for the KIX protein.
Spring 2014 - Congratulations to second year students, Andrew Urick, Brie Perell, and Clifford Gee for passing qualifying exams and obtaining Ph.D. candidate status!
January 27th, 2014 - Pomerantz lab runs the first Chemical Biology Boot Camp, providing new students with the opportunity to learn basic chemical biology lab skills.
June 22nd, 2013 - The Pomerantz Lab and the Haynes lab participate in a summer outreach event at the West 7th Community Center and demo their new fingerprint detection and DNA isolation experiments as part of the Haynes lab "solar cell heist mystery"
June 19th, 2013 - The Pomerantz lab runs the first Chemical Biology short course with the Osher Life Long Learning Institute. Great work, Andrew, Drew, and Brie!
June 13th, Pomerantz Lab receives an American Cancer Society IRG grant
Newest Acquisition; Bruker TCI CRYO Prodigy Probe for 500 MHz NMR (19F S/N; 2100:1)