University of Minnesota
University of Minnesota
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Topczewski Group

Publications

Independent Career:

3) Packard, M. H.; Cox, J. H.; Suding, V. P.; Topczewski, J. J. "The Effect of Proximal Functionality on the Allylic Azide Equilibrium" Euro. J. Org. Chem. 2017. (DOI: 10.1002/ejoc.201700693)

2) Ott, A. A.; Goshey, C. S.; Topczewski, J. J. “Dynamic Kinetic Resolution of Allylic Azides via Asymmetric Dihydroxylation” J. Am. Chem. Soc. 2017, 139, 7737. (DOI: 10.1021/jacs.7b04203)

1) Goswami, P. P.; Suding, V. P.; Carlson, A. S.; Topczewski, J. J. “Direct Conversion of Aldehydes and Ketones to Azides via Sequential Nucleophilic Addition & Substitution” Eur. J. Org. Chem. 2016, 28, 4809.(DOI: 10.1002/ejoc.201600856)

Mentored Career:

21) Topczewski, J. J.; Cabrera, P. J.; Saper, N. I.; Sanford, M. S. “Palladium-Catalyzed Transannular C–H Functionalization of Alicyclic Amines” Nature 2016, 531, 220. (DOI:10.1038/nature16957)

20) Morril, J. A.; Topczewski, J. J.; Lodge, A. M.; Yasapala, N. Y.; Quinn, D. M. “Development of quantitative structure activity relationships for the binding affinity of methoxypyridinium cations for human acetylcholinesterase” J. Mol. Graphics Modell 2015, 62, 181. (DOI:10.1016/j.jmgm.2015.09.016)

19) Zhang, Q.; Stockdale, D.; Mixdorf, J. C.; Topczewski, J. J.; Nguyen, H. M. “Iridium-Catalyzed Enantioselective Fluorination of Racemic, Secondary Allylic Trichloroacetimidates” J. Am. Chem. Soc. 2015, 137, 11912. (DOI: 10.1021/jacs.5b07492).

18) Ichiishi, N.; Brooks, A. F.; Topczewski, J. J.; Rodnick, M. E.; Sanford, M. S.; Scott, P. J. H. “[18F]Fluorination of (Mesityl)(Aryl)Iodonium Salts” Radiochemical Syntheses 2015, Ch.14. (DOI: 10.1002/9781118834114.ch14)

17) Topczewski, J. J.; Sanford, M. S. “Carbon-Hydrogen (C-H) Bond Activation at Pd(IV): A Frontier in Catalysis” Chem. Sci. 2015, 6, 70. (Invited Review) (DOI: 10.1039/c4sc02591a)

16) Brooks, A. F.; Topczewski, J. J.; Ichiishi, N.; Sanford, M. S.; Scott, P. J. H. “Late-stage [18F]Fluorination: New Solutions to Old Problems” Chem. Sci. 2014, 5, 4545. (DOI: 10.1039/C4SC02099E)

15) Ichiishi, N.; Brooks, A. F.; Topczewski, J. J.; Rodnick, M. E.; Sanford, M. S.; Scott, P. J. H. “Copper-Catalyzed [18F]Fluorination of (Mesityl)(aryl)iodonium Salts” Org. Lett. 2014, 16, 3224. (DOI: 10.1021/ol501243g)

14) Scott, P. J. H.; Sanford, M. S.; Ichiishi, N.; Brooks, A. F.; Rodnick, M. E. and Topczewski, J. J. "Copper Catalyzed [18F]Fluorination of Iodonium Salts" U. S. Patent Application Serial Number 61/978,646, filed 11 April 2014.

13) Quinn, D. M. and Topczewski, J. J. "Compounds and Methods to Treat Organophosphorus Poisoning" U. S. Patent Application Number 14163859, filed 24 January 2014.

12) Topczewski, J. J.; Lodge, A. M.; Yasapala, S. N.; Payne, M. K.; Keshavarzi, P. M.; Quinn, D. M. “Reversible Inhibition of Human Acetylcholinesterase by Methoxypyridinium Species” Bioorg. Med. Chem. Lett. 2013, 23, 5786. (DOI:10.1016/j.bmcl.2013.09.008)

11) Kodet, J. G.; Topczewski, J. J.; Gardner, K. D.; Wiemer, D. F. “Electrophilic Prenylation via Cascade Cyclization” Tetrahedron 2013, 44, 9212. (DOI: 10.1016/j.tet.2013.08.056)

10) Topczewski, J. J.; Quinn, D. M. “Kinetic Assessment of N-Methyl-2-Methoxypyridinium Species as Phosphonate Anion Methylating Agents” Org. Lett. 2013, 15, 1084. (DOI: 10.1021/ol400054m)

9) Topczewski, J. J.; Tewson, T. J.; Nguyen, H. M. “Iridium-Catalyzed Allylic Fluorination of Trichloroacetimidates” J. Am. Chem. Soc. 2011, 133, 19318. (DOI: 10.1021/ja2087213)

8) Topczewski, J. J. “Cascade Cyclizations and the Schweinfurthins” Ph.D. Thesis, University of Iowa, Iowa City, IA, 2011

7) Topczewski, J. J.; Callahan, M. P.; Kodet, J. G.; Inbarasu, J. D.; Mente, N. R.; Beutler, J. A.; Wiemer, D. F. “Relevance of the C-5 Position to Schweinfurthin Induced Cytotoxicity” Bioorg. Med. Chem. 2011, 19, 7570. (DOI: 10.1016/j.bmc.2011.10.034)

6) Topczewski, J. J.; Wiemer, D. F. “First Total Synthesis of (+)-Vedelianin, a Potent Anti-proliferative Agent” Tetrahedron Lett. 2011, 52, 1628. (DOI:10.1016/j.tetlet.2011.01.137)

5) Topczewski, J. J.; Kodet, J. G.; Wiemer, D. F. “Exploration of Cascade Cyclizations Terminated by Tandem Aromatic Substitution: Total Synthesis of (+)-Schweinfurthin A” J. Org. Chem. 2011, 76, 909. (DOI: 10.1021/jo1022102)

4) Topczewski, J. J.; Kuder, C. H.; Neighbors, J. D.; Hohl, R. J.; Wiemer, D. F. “Fluorescent Schweinfurthin B and F Analogs with Anti-proliferative Activity” Bioorg. Med. Chem. 2010, 18, 6734. (DOI: 10.1016/j.bmc.2010.07.056)

3) Topczewski, J. J.; Callahan, M. P.; Neighbors, J. D.; Wiemer, D. F. “A Tandem Cascade Cyclization-Electrophilic Aromatic Substitution: Application in the Total Synthesis of (+)-Angelichalcone” J. Am. Chem. Soc. 2009, 131, 14630. (DOI: 10.1021/ja906468v)

2) Topczewski, J. J.; Neighbors, J. D.; Wiemer, D. F. “Total Synthesis of (+)-Schweinfurthins B and E” J. Org. Chem. 2009, 74, 6965. (DOI: 10.1021/jo901161m)

1) Neighbors, J. D.; Topczewski, J. J.; Swenson, D. C.; Wiemer D. F. “Synthesis of the Cis-Fused Hexahydroxanthene System via Cationic Cascade Cyclization” Tetrahedron Lett. 2009, 50, 3881. (doi:10.1016/j.tetlet.2009.04.052)