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Impacts of Mesoporous Silica Nanoparticle Size, Pore Ordering, and Pore Integrity on Hemolytic Activity

Recent research from the research group of Professor Christy Haynes.

Recently, the Haynes group has systematically studied the hemolytic activity of nonporous and porous silica nanoparticles with varied sizes using a hemolysis assay. The motivation for this work lies in the great potential of these nanoparticles as drug delivery agents. The result shows that porous silica nanoparticles have lower hemolytic activity than their similarly sized nonporous counterparts, likely due to fewer silanol groups on the cell-contactable surface of the porous silica nanoparticles. In addition, the authors find the extent of hemolysis by mesoporous silica nanoparticles increases as the pore structure is compromised by mild aging in saline, initiating dissolution of silica and leading to pore collapse (as shown in the TEM images below). This effect has never before been investigated in silica nanotoxicity studies and has significant implications for the future use of these materials. Furthermore, the porous silica nanoparticle-induced hemolysis can be eliminated by modifying the nanoparticle surface with a poly(ethylene glycol) coating during nanoparticle synthesis.

This work was recently reported in the Journal of the American Chemical Society (Lin, Y.-S.; Haynes, C. L. J. Am. Chem. Soc. 2010, 132, 4834-4842).


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