Conference Schedule and Scientific Program
Conference Schedule and Scientific Program |
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Symposium participants will receive a "Program and Abstracts" book when they check in at the on-site registration desk, which will be open from 11:00 a.m. - 7 p.m. on Saturday, June 26, 1999, from 7:30 a.m. - 6:30 p.m. on Sunday, June 27, 1999, and at later times in the week. The aforementioned book will contain the detailed scientific program and abstracts for each of the oral presentations (summarized further below on this web page) and poster presentations (a complete list will be posted approximately May 24, 1999). Presenting authors only are listed, but a searchable index is now available listing coauthors. All lectures have L numbers, in parentheses after the title, and in the separate list of poster presentations, P numbers are provided. Young Investigators' MiniSymposium lectures are all also presented as posters, and hence the P number is given. In addition, several speakers have elected to present posters corresponding to their lectures and/or refer Symposium participants to relevant poster presentations by their coworkers, as is indicated in the following. For general information about the Symposium, return to the home page.
| Saturday, June 26, 1999
Young Investigators' MiniSymposium dedicated to the memory of Bruce W. Erickson, Ballroom A, 4:00 p.m. - 7:00 p.m., Chairs: Jane V. Aldrich and Arthur M. Felix |
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| Session I, 4:00 p.m. - 5:25 p.m. | |||
| Matthew J. Saderholm | Engineering of Cysteine-Containing Variants of Quadrin and Deltoid, Two Proteins Containing the Oligomerization Site of the Hepatitis Delta Antigen. (P363). | ||
| Thorsten Oost | Design and Synthesis of Inhibitors of Botulinum Neurotoxin A and B Proteases. (P615). | ||
| Michael Shultz | Design, Synthesis, and Evaluation of a Small Library of Rationally Designed Dimerization Inhibitors of HIV-1 Protease. (P616). | ||
| Assaf Friedler | Backbone Cyclic Proteinomimetics Derived from the Arginine-Rich Domain of HIV-1 Tat and Rev Proteins: One Sequence, Two Conformations, Two Biological Functions. (P821). | ||
| Dongxia Wang | Cyclic Dodecapeptides (LLLD)3 Form Ion Channels in Lipid Membranes. (P384). | ||
| Scott Mitchell | The Synthesis of Several O-Glycopeptide Analogs of Enkephalin. (P146). | ||
| Session II, 5:45 p.m. - 7:00 p.m. | |||
| Amareth Lim | Characterization of Betabellins 15D and 16D, Designed Beta-Sandwich Proteins That Have Amyloidogenic Properties. (P362). | ||
| Kenneth S. Rotondi | Investigating the Role of Turns in the Folding of a Primarily b-Sheet Protein. (P333). | ||
| Natalia Carulla | Design, Synthesis and Characterization of a Core Module of Bovine Pancreatic Trypsin Inhibitor. (P329). | ||
| Elsa Locardi | Receptor Bound Conformations of Integrin aIIbb3 Antagonists by 15N-Edited NMR Spectroscopy. (P258). | ||
| Heekyung Choi | Synthesis and Evaluation of Potential Affinity Labels for Opioid Receptors. (P428). | ||
| Josue Alfaro-Lopez | The Fine Tuning of High Affinity and Selective Non-Peptide Agonists of the d-Opioid Receptor via Solution and Solid-Phase Formats. (P207). | ||
| Opening Mixer and Reception, sponsored by Multiple Peptide Systems, Convention Center Plaza, 7:00 p.m. - 9:30 p.m. | |||
| Sunday, June 27, 1999 | |||
| Welcome and Introduction, Ballroom A, 8:05 a.m. - 8:30 a.m., Symposium co-Chairs George Barany and Gregg B. Fields, and special guest Mark G. Yudof, President of the University of Minnesota. | |||
| Plenary I - Ballroom A: Peptide Design & Signal Transduction, 8:30 a.m. - 10:00 a.m., Chairs: Miklos Bodanszky and Robert S. Hodges | |||
| Dennis A. Dougherty | The Cation-p Interaction: From Structural Biology to Neuroreceptor Binding Sites. (L002). | ||
| Masashi Yanagisawa | Reverse Pharmacology of Brain Peptides: Discovery and Function of Orexins. (L003). | ||
| Herbert Waldmann | Chemoenzymatic Synthesis of Lipidated Peptide and Protein Conjugates -- Tools for the Study of Biological Signal Transduction. (L004; see also P154). | ||
| Plenary II - Ballroom A: Genomics & Peptide Science, sponsored by Gryphon Sciences, 10:30 a.m. - 12:30 p.m., Chairs: Stephen B.H. Kent and Garland R. Marshall | |||
| Ruedi Aebersold | The Proteome: Analysis and Utility. (L005). | ||
| Baldomero M. Olivera | Conus Peptides: Post-Translational Modification and Hypermutation are Strategies for Generating Molecular Diversity. (L006). | ||
| Paul Alewood | Conotoxins in Drug Design. (L007). | ||
| Stephen B.H. Kent | Total Chemical Synthesis of Proteins. (L008; also presented as a poster). | ||
| Tom W. Muir | Expressed Protein Ligation: A New Tool for Studying Protein Structure and Function. (L009; also presented as a poster). | ||
| Concurrent I - Ballroom A: Peptide & Peptidomimetic Therapeutics I, 2:30 p.m. - 4:30 p.m., Chairs: Kenneth D. Kopple and Peter W. Schiller | |||
| Lihu Yang | The Design and Synthesis of Non-Peptide Somatostatin Receptor Agonists. (L010; also presented as a poster). | ||
| Horst Kessler | Recent Progress in the Field of avb3 Integrin Antagonists (L011; see also P216). | ||
| James B. McCarthy | A Novel Peptide Motif That Inhibits Integrin Mediated Adhesion. (L012). | ||
| Ziwei Huang | Control of Apoptosis by Using Small Molecule Regulators of Bcl-2 Family Proteins. (L013). | ||
| Kathryn S. Prickett | Gila Monsters, Exendin-4 and Diabetes. (L014). | ||
| John M. Stewart | Bradykinin Antagonists: Anti-Cancer Drugs for the New Millennium? (L015; see also P490 and P491). | ||
| Robert T. Jacobs | The Discovery of Orally-Active Pseudopeptide Antagonists of the Atrial Natriuretic Peptide Clearance Receptor. (L016; see also P511 and P512). | ||
| Fortuna Haviv | The Design of LHRH Antagonist Mimetics. (L017; see also P494). | ||
| Concurrent II - Ballroom B: Design & Folding, 2:30 p.m. - 4:30 p.m., Chairs: Jean Chmielewski and Robert P. Hammer | |||
| Glenn L. Millhauser | Talking About TOAC -- A Novel Electron Spin Resonance Probe of Peptide Conformation. (L018). | ||
| John W. Taylor | A Calorimetric Study of the Helix-Coil Transition Using a Side-Chain Bridged Peptide That Folds and Unfolds Cooperatively. (L019; see also P323). | ||
| Isabella L. Karle | Hydrogen-Bonded Self-Assembled Peptide Nanotubes from Cystine-Based Macrocycles Containing Bisurea or Hydrocarbon Segments. (L020). | ||
| Ernest Giralt | Self-Assembly of Synthetic Peptides: Formation of Amphipathic Surfaces and Head-to-Tail Self-Assembly. (L021). | ||
| Aphrodite Kapurniotu | Amyloid Fibril Formation by Partially Unfolded Islet Amyloid Polypeptide (IAPP). (L022; also presented as a poster). | ||
| Lars Baltzer | Catalysis of Pyridoxal Phosphate Mediated Transamination. (L023; see also P369). | ||
| Mark D. Distefano | Semisynthetic Approaches for the Design of Proteins with Catalytic Activity (L024; see also P095, P389, and 390). | ||
| Robert W. Janes | Structural Studies on a-Conotoxin SI. (L025; also presented as a poster). | ||
| Poster Session I, Exhibit Hall 1, 4:30 p.m. - 6:30 p.m. Synthetic Methodologies (including large-scale synthesis), P001-P113 Peptide Conjugates (including glycopeptides and phosphopeptides), P141-P169 Solid-Phase Organic Synthesis & Combinatorial Methods, P197-P230 |
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| Junior Symposium, Exhibit Hall 1, 4:30 p.m. - 6:30 p.m. | |||
| Exhibitor workshop, Room 101ABJI : Automated Peptide Solutions, sponsored by PE Biosystems, 6:30 p.m. - 8:30 p.m. Click here to register for this workshop. | |||
| Exhibitor workshop, Room Four Seasons Lounge, Protein Identification and Ion Trap Mass Spectrometry, sponsored by ThermoQuest, 6:30 - 8:30 p.m. | |||
| Monday, June 28, 1999 | |||
| Plenary III - Ballroom A: Peptide Applications for Biological Systems, 8:30 a.m. - 10:00 a.m., Chairs: Lila M. Gierasch and Yasutsugu Shimonishi | |||
| Dana L. Johnson | Peptide Mimetics of Erythropoietin are Powerful Probes of Receptor Activation Mechanisms. (L026). | ||
| Cynthia L. Stevenson | Implant and Transdermal Innovations for Peptide and Protein Delivery. (L027). | ||
| Jonathan A. Ellman | Targeted Libraries. (L028). | ||
| Guy S. Salvesen | How to Trigger Programmed Cell Death. (L029). | Plenary IV - Ballroom A: Peptide Design & Biomaterial Applications, 10:30 a.m. - 12:30 p.m., Chairs: Jean Baum and Daniel H. Rich | |
| Jeffery W. Kelly | Peptidomimetic Monolayers That Nucleate Cadmium Sulfide Nanocrystals. (L031). | ||
| Lynne Regan | The Design of Alpha Helices and Beta Sheets and Their Interconversion. (L032). | ||
| Robert S. Hodges | The Importance of Secondary Structure Specificity Determinants in Protein Folding. (L033; see also P320). | ||
| Lila M. Gierasch | Roles of Proline Residues in the Structure and Folding of a b-Clam Protein. (L034). | ||
| Charles M. Deber | Helicity and Hydrophobicity: Folding Peptides into Membranes. (L035; see also P346 and P582). | ||
| Concurrent III - Ballroom A: Solid-Phase Organic Synthesis, 2:30 p.m. - 4:30 p.m., Chairs: Jonathan A. Ellman and Ronald Frank | |||
| Kit S. Lam | The Use of an On-Bead Whole Cell Binding Assay to Identify Biologically Active Peptides From "One-Bead One-Compound" Combinatorial Peptide Libraries. (L036). | ||
| Ulrich Reineke | Identification of Miniproteins Using Cellulose-Bound Duotope Scans. (L037; also presented as a poster). | ||
| Michal Lebl | New Technique for High Throughput Synthesis of Peptides, Peptidomimetics, and Nonpeptide Small Organic Molecule Arrays. (L038; also presented as a poster). | ||
| Morten Meldal | SPOCC Resins: Polar and Chemically Inert Resins for Organic Synthesis and Enzyme Library Assays (L039). | ||
| Oleg Melnyk | New Methodologies for the Solid Phase Synthesis of Hydrazinopeptides, C-Terminal Peptide Aldehydes and for the Chemical Ligation of Unprotected Peptide Fragments. (L040; see also P066 and P107). | ||
| Mark L. Smythe | New Linkers, Cyclisation Auxiliaries and Diversity Metrics for the Synthesis of Focussed Cyclic Peptide Libraries. (L041; see also P225). | ||
| Wim Meutermans | Synthesis of Small Cyclic Peptides: An Auxiliary Approach to Address the "Difficult Cyclisation" Problem. (L042; also presented as a poster). | ||
| Mark A. Lipton | Solid Phase Synthesis and Structure Determination of the Cyclic Depsipeptide Callipeltin B. (L043). | ||
| Concurrent IV - Ballroom B: Design & Biology, 2:30 p.m. - 4:30 p.m., Chairs: Cynthia L. Stevenson and John M. Stewart | |||
| Kevin H. Mayo | Anginex, a Designed Peptide Cytokine That Inhibits Angiogenesis and Tumor Growth in Mice. (L044). | ||
| Teruna J. Siahaan | Utilization of Cell-Adhesion Peptides to Improve Drug Delivery. (L045; see also P527 and P753). | ||
| Robin Polt | Practical Glycopeptide Analgesics. Blood-Brain Barrier (BBB) Transport and Binding of Glycosylated Enkephalin Analogs. (L046; see also P146 and P394). | ||
| Bernhard Kutscher | New LHRH Antagonists with Enhanced Biological Activity: Preclinical and Clinical Results. (L047). | ||
| Leonard G. Contillo | Glucagon-like Peptide-1 and its Analogs: A Structure/Function Analysis. (L048). | ||
| Laszlo Otvos, Jr. | Chemical and Biological Consequences of Sugar Incorporation into a Potential N-Glycosylation Site in the Tubulin-Binding Repeat of Tau Protein. (L049; also presented as a poster). | ||
| Henry B. Lowman | Mapping the Binding Epitope of a Phage-Library Derived Peptide That Inhibits IGFBP-1 Binding to Insulin-like Growth Factor. (L050). | ||
| Michael C. Pirrung | Preparation and Incorporation into Small Peptides and Combinatorial Libraries of Phosphohistidine Analogs for Study of Prokaryotic Two-Component Signal Transduction Systems. (L051). | ||
| Poster Session II, 4:30 p.m. - 6:30 p.m., Exhibit Hall 1 Analytical & Biophysical Methods, P258-P293 Design & Folding, P320-P399 Peptide-based Biomaterials, P423-P444 Peptide & Peptidomimetic Therapeutics & Delivery, P472-P536 |
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| Workshop, Room 205ABCD, Analysis of Synthetic Peptides, sponsored by Association of Biomolecular Resource Facilities (ABRF), 7:00 p.m. - 8:30 p.m. | |||
| Exhibitor workshop, Seasons Lounge, New Directions in Combinatorial Chemistry: Technology for the Next Millennium, sponsored by Advanced Chemtech, 7:30 p.m. - 9:00 p.m. | |||
| Ronald Frank | Advanced ChemTech Award in Combinatorial Library Sciences Lecture: A Rational Approach to Complex Problems: The Combinatorial Way. | ||
| Tuesday, June 29, 1999 | |||
| Plenary V - Ballroom A: Targetted Peptide Engineering, 8:30 a.m. - 10:00 a.m., Chairs: Steven A. Kates and Arno F. Spatola | |||
| Richard A. Houghten | The Use of Mixture-based Combinatorial Libraries to Identify T-Cell Specific Antigens. (L052; also presented as a poster). | ||
| Claudio Toniolo | The Peptide 310-Helix: Historical Backgrounds and Recent Structural Studies and Applications. (L053). | ||
| Geoffrey W. Tregear | Relaxin and Relaxin-Related Peptides: Synthesis, Structure and Biological Function. (L054; see also P870). | ||
| Concurrent V - Ballroom A: Synthetic Methodologies I, 10:30 a.m. - 11:30 a.m., Chairs: John D. Wade and Samuel Zalipsky | |||
| Keith Rose | Polyethyleneglycol-Based Chains of Precise Length and Chemobodies. (L055). | ||
| Ian R. Cottingham | Novel Methods of Making (Amidated) Peptides - Rapid Gram Quantities as Intein Fusions and Ton Quantities from Fusion Proteins in the Milk of Transgenic Animals. (L056; also presented as a poster). | ||
| Wolfgang Haehnel | Combinatorial Synthesis of De Novo Metallo-Proteins With Tuned Redox Potential. (L057). | ||
| Concurrent VI - Ballroom B: Peptide Immunology, 10:30 a.m. - 11:30 a.m., Chairs: Lenore I. Martin and John Smith | |||
| Sam D. Sanderson | Induction of an Antigen-Specific CTL Immune Response by a Conformationally Biased Agonist of C5A Anaphylatoxin as a Molecular Adjuvant. (L058; also presented as a poster). | ||
| Pravin T.P. Kaumaya | Incremental Multi-epitope Vaccine Strategies for Immunotherapy of Cancer and Retroviral Infections. (L059l; see also P748, P749, P751, and P752). | ||
| David Andreu | Can a Discontinuous Viral Antigenic Site Be Chemically Reproduced? A Rational Approach to a Difficult Problem. (L060). | ||
| The 1999 Merrifield Award (sponsored by Rao Makineni), 11:40 a.m.- 1:00 p.m., Chairs: Ralph F. Hirschmann and Bruce Merrifield; Introduction by George Barany | |||
| Daniel H. Rich | Rao Makineni Lecture: Mimetic Peptides, Demanding Enzymes, and Drug Discovery. (L001). | ||
| Free afternoon and evening, starts at 1:00 p.m. | |||
| Two optional organized activities both start at 2:00 p.m.; these are the Stillwater/St. Croix River excursion and the First American Peptide Symposium Golf Tournament, hosted by Mallinckrodt Inc. | |||
| Wednesday, June 30, 1999 | |||
| Plenary VI - Ballroom A: Proteases & Protease Inhibitors, 8:30 a.m. - 10:00 a.m., Chairs: Yoshiaki Kiso and Teresa M. Kubiak | |||
| Daniel F. Veber | Emil Kaiser, Sr. Lecture: Novel Inhibitor Classes Directed at the Osteoclast Specific Cysteine Protease, Cathepsin K. (L061). | ||
| Ben M. Dunn | Selectivity in Inhibition of Proteolytic Enzymes From Plasmodium Falciparum. (L062). | ||
| Hideaki Nagase | Structural Requirements for Collagenolytic Activity of Matrix Metalloproteinase 1 (MMP-1). (L063; also presented as a poster; see also P637 and P638). | ||
| Plenary VII - Ballroom A: Non-Globular Proteins: Folding & Function, 10:30 a.m. - 12:30 p.m., Chairs, Gregg B. Fields and Yu-Cang Du | |||
| Darwin J. Prockop | Use of Synthetic Peptides to Define Binding Sites in Collagen I for Self-Assembly into Fibers and for Interaction with Other Matrix Molecules. (L064). | ||
| Jean Baum | NMR Folding of Peptide Models of Collagen and Misfolding in Disease. (L065). | ||
| Murray Goodman | Design, Synthesis and Conformations of Novel Triple Helical Collagen Mimetic Structures. (L066; also presented as a poster). | ||
| Ronald T. Raines | Hyperstable Collagen Mimics. (L067; see also P352, P353, and P440). | ||
| Luis Moroder | Heterotrimeric Collagen Peptides as Substrates of Metalloproteinases. (L069). | ||
| Concurrent VII - Ballroom A: Synthetic Methodologies II, 2:30 p.m. - 4:30 p.m., Chairs: Derek Hudson and Jean E. Rivier | |||
| Mark L. McLaughlin | Constrained Amino Acid Analogs in De Novo Peptide Design. (L070; see also P564). | ||
| James J. Mencel | Process Research Toward Scale-Up and Industrial Preparation of RPR 109891 (Klerval). (L071). | ||
| Jean Martinez | Synthesis and Pharmacological Evaluation of a New Series of Bombesin Analogs (L072). | ||
| Hack-Joo Kim | Na-2-(4-Nitrophenylsulfonyl)ethoxycarbonyl (Nsc) as a New Amino-Protecting Group and its Application for Peptide Synthesis. (L073; see also P023, P025, and P027). | ||
| Robert P. Hammer | Synthesis of Phosphonate and Thiophosphonate Peptide Analogs as Inhibitors of Carboxypeptidase A. (L074; also presented as a poster; see also P029). | ||
| Chaim Gilon | In Situ Generation of Fmoc-AA Chlorides for Extremely Difficult Couplings to Sterically Hindered Secondary Amines in Solid Phase Peptide Synthesis. (L075; also presented as a poster). | ||
| Zhenwei Miao | Orthogonal Segment Ligation. (L076; also presented as a poster). | ||
| William D. Lubell | Mimicry of Peptide Turn Back-Bone and Side-Chain Interactions: Synthesis of 5- and 7-Hydroxymethyl Indolizidinone Amino Acids. (L077). | ||
| Concurrent VIII - Ballroom B: Enzymes & Enzyme Inhibitors, 2:30 p.m. - 4:30 p.m., Chairs: Ben M. Dunn and Daniel F. Veber | |||
| A. Ian Smith | A Novel Stable Inhibitor of Endopeptidases EC 3.4.24.15 & 3.4.24.16 Potentiates Bradykinin Induced Hypotension. (L078). | ||
| Phaedria M. St. Hilaire | A Combinatorial Approach to the Identification of Cysteine Protease Substrates and Inhibitors by Application of a Solid-Phase Fluorescent Quenching Assay. (L079). | ||
| Ching H. Tung | In Situ Detection of Tumor Associated Protease Activity Using Long Circulating Fluorescent Labeled Peptide Substrates. (L080). | ||
| Antonello Pessi | Structural Studies of Peptide Inhibitors Bound to Human Hepatitis C Virus Protease Yield Insights into the Mechanism of Action of the Enzyme. (L081). | ||
| Yoshiaki Kiso | Small Dipeptide-Based HIV Protease Inhibitors and Prodrug-Type Conjugates with AZT. (L082; see also P517). | ||
| Felicia A. Etzkorn | (Z)-Alkene Phospho-Ser-cis-Pro Substrate Analog for Pin-1, a Phosphorylation-Dependent Peptidyl-Prolyl-Isomerase. (L083; also presented as a poster). | ||
| David Corey | Positive and Negative Selectivity in Protease Evolution: Investigation of the Specificities of Plasmin, T-PA, U-PA, and PSA Using Substrate Phage Display and Kinetic Analysis of Peptide and Protein Substrates. (L084). | ||
| Barry S. Cooperman | C-Terminal Peptides as Inhibitors and Probes of Enzyme Function. Mammalian Ribonucleotide Reductase. (L085; see also P513, P514, and P515). | ||
| Poster Session III, Exhibit Hall 1, 4:30 - 6:30 p.m. Membrane-active Peptide Antibiotics & Neurotoxins, P563-P584 Enzymes & Enzyme Inhibitors, P614-P639 Signal Transduction (including G-protein-coupled transmembrane receptors), P669-P700 Immunological Roles for Peptides (including vaccine development), P729-P755 Molecular Mechanisms of Amyloid-based Diseases, P785-P790 Proteomics, P820-P824 Peptide Biology, P853-P873 |
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| Thursday, July 1, 1999 | ||||
| Plenary VIII - Ballroom A: Peptide Activity & Delivery, 8:30 - 10:20 a.m., Chairs: Charles M. Deber and Victor J. Hruby | ||||
| Andrew D. Hamilton | Toward Artificial Antibodies: Protein Surface Recognition by Synthetic Receptors. (L086). | |||
| Matthew Tirrell | Ligand Accessibility as a Means to Control Cell Response to Bioactive Bilayer Membranes. (L030). | |||
| Fred Naider | Biophysical Studies on the Transmembrane Peptide of the Yeast a-Factor Receptor. (L087; see also P268). | |||
| Binghe Wang | Delivering Peptides and Peptidomimetics Across Membrane Barriers. A Prodrug Approach. (L088). | |||
| Tomi K. Sawyer | Peptidomimetic and Nonpeptide Inhibitors of pp60src Tyrosine Kinase: Structure, Mechanisms, and Drug Discovery. (L089; see also P669). | |||
| Plenary IX - Ballroom A: Analytical & Biophysical Methods, 10:50 a.m. - 12:35 p.m., Chairs: Judd Berman and Eric J. Munson | ||||
| Paul A. Keifer | NMR Analysis Tools for the Peptide Sciences. (L090). | |||
| Ralf Warrass | Studying Structures Attached to Solid Supports by High Resolution Magic Angle Spinning NMR (HR MAS NMR). (L091; also presented as a poster). | |||
| Sean M. Decatur | Analysis of Local Conformation Within Helical Peptides via Isotope-Edited Vibrational Spectroscopy. (L092; see also P272 and P322). | |||
| Bing Yan | Analytical Tools for the Reaction Optimization Stage of the Solid-Phase Combinatorial Synthesis. (L093). | |||
| Ruth Hogue Angeletti | Hydrogen/Deuterium Exchange Coupled With Mass Spectrometry Identifies Extensive Conformational Changes in Purine Nucleoside Phosphorylase Caused by a Transition State Inhibitor. (L094). | |||
| On Thursday, July 1, a complimentary lunch to all registered Symposium participants will be served at the Convention Center (note that the break between morning and afternoon sessions is shorter than usual). | ||||
| Concurrent IX - Ballroom A: Signal Transduction I, 2:15 p.m. - 4:00 p.m., Chairs: Mark A. Jarosinski and Tomi K. Sawyer | ||||
| Victor J. Hruby | Efficacy: What Is It and Why You Should Care! (L095). | |||
| Annette G. Beck-Sickinger | Development of the First CGRP-Antagonist with Nanomolar Affinity. (L096). | |||
| Carrie Haskell-Luevano | Point Mutation in TM6 of the Melanocortin-4 Receptor Results in Agonist Activity of the MC4R Antagonist (SHU9119). (L097; also presented as a poster). | |||
| Peter P. Roller | High Affinity Nonphosphorylated Cyclic Peptide Inhibitors of Grb2-SH2 / Growth Factor Receptor Interactions. (L098; also presented as a poster). | |||
| Terrence R. Burke, Jr. | Design and Synthesis of a New Tyrosine Analogue Having c1 and c2 Angles Constrained to Values Observed for an SH2 Domain-Bound Phosphotyrosyl Residue. (L099; also presented as a poster). | |||
| John S. McMurray | Phosphotyrosyl Peptides Targeted to the SH2 Domain are Potent Inhibitors of the Kinase Activity of pp60c-src. (L100). | |||
| Dale F. Mierke | Molecular Characterization of the Interaction Between Parathyroid Hormone and its Receptor. (L101). | |||
| Concurrent X - Ballroom B: Protein Design & Function, 2:15 p.m. - 4:00 p.m., Chairs: Isabella L. Karle and Tim Keiderling | ||||
| Jean Chmielewski | Expanding the Repertoire of Helical Bundles: Stabilization of Five+ Helix Bundles. (L102; see also P358). | |||
| Yuji Hidaka | The Mechanism of the Propeptide-Mediated Folding of Guanylyl Cyclase Activating Peptides. (L103; also presented as a poster). | |||
| Elisar Barbar | Dynamics and Stability of Partially Folded and Unfolded Conformations of Bovine Pancreatic Trypsin Inhibitor. (L104; also presented as a poster). | |||
| Claudio Vita | Rational Engineering of a Miniprotein Inhibitor of HIV-1 Infectivity. (L105). | |||
| B. A. Wallace | Antiamoebin: A Polypeptide Ion Carrier and Channel. (L106). | |||
| David H. Live | Insights into Glycoproteins - A Structural Motif for Mucins from a Glycopeptide. (L107; also presented as a poster). | |||
| W. L. Duax | Gramicidin A: Structure and Dynamic Properties. (L108; also presented as a poster). | |||
| Concurrent XI - Ballroom A: Peptide & Peptidomimetic Therapeutics II, 4:30 p.m. - 5:30 p.m., Chairs: Jed F. Fisher and Jean Martinez | ||||
| Robin E. Offord | Rational Development of an Anti-HIV Protein Active at Low Picomolar Concentrations. (L109; see also P163). | |||
| Barry A. Morgan | Identification and Exploitation of Structural Foci That Influence Conformational Mobility in Somatostatin Agonists and Antagonists. (L110). | |||
| Michael Kahn | Secondary Structure Templated Libraries: Biological Probes and Drug Discovery. (L111). | |||
| Jean Gariépy | Loligomers: Multi-Tasking Intracellular Peptide Shuttles. (L112). | |||
| Concurrent XII - Ballroom B: Signal Transduction II, 4:30 p.m. - 5:30 p.m., Chairs: Deborah A. Kallick and Raniero Rocchi | ||||
| Carlos García-Echeverría | Potent Grb2-SH2 Antagonists Containing Asparagine Mimetics. (L113). | |||
| Jane V. Aldrich | Novel Opioid Peptides as Kappa Opioid Receptor Antagonists. (L114). | |||
| Mark A. Jarosinski | SAR of the Novel Neuropeptides Orexin-A and B. (L115). | |||
| Julia Brown | Peptide Mimetics of Receptor Extracellular Domains Modulate Signal Transduction by P2Y Receptors. (L116). | |||
| Plenary X - Ballroom B: Perspectives For The New Millenium, 5:45 p.m. - 6:30 p.m., Chair Bruce Merrifield | ||||
| This will be a high powered panel discussion convened by Bruce Merrifield of The Rockefeller University. | ||||
| Social hour, Main Lobbies, 7:30 p.m. - 8:30 p.m. | ||||
| Banquet, Ballroom A, 8:30 p.m. - 11:30 p.m. | ||||
On-Site Registration/Information Desk
| Saturday, June 26 | 11:00 a.m. | - | 7:00 p.m. |
| Sunday, June 27 | 7:30 a.m. | - | 6:30 p.m. |
| Monday, June 28 | 7:30 a.m. | - | 5:00 p.m. |
| Tuesday, June 29 | 7:30 a.m. | - | 5:00 p.m. |
| Wednesday, June 30 | 7:30 a.m. | - | 5:00 p.m. |
| Thursday, July 1 | 7:30 a.m. | - | 5:00 p.m. |
| Sunday, June 27 | 10:00 a.m. | - | 7:00 p.m. |
| Monday, June 28 | 8:00 a.m. | - | 7:00 p.m. |
| Tuesday, June 29 | 8:00 a.m. | - | 12:00 noon |
| Wednesday, June 30 | 8:00 a.m. | - | 5:00 p.m. |
| Sunday, June 27 | 10:00 a.m. | - | 10:00 p.m. |
| Monday, June 28 | 8:00 a.m. | - | 10:00 p.m. |
| Tuesday, June 29 | 8:00 a.m. | - | 10:00 p.m. |
| Wednesday, June 30 | 8:00 a.m. | - | 10:00 p.m. |
| Thursday, July 1 | 8:00 a.m. | - | 2:00 p.m. |