Chemistry 4361/8361
Interpretation of Organic Spectra
Lecture and Workshop Schedule
| Date | Lecture Topic | Readings |
| Wed, Sep 5 |
Introduction | Required:
Lambert 1.1-1.5 |
| Fri, Sep 7 | NMR--Nuclear Spin and the NMR Phenomenon | Required:
Lambert 2.1-2.5 Recommended: Claridge 1.1-2.3 |
| Mon, Sep 10 |
NMR--Relaxation
and the FID
In-Class Exercise: Using NMR to Analyze a Typical Chemical Reaction |
Required:
Lambert 2.6-2.10 |
| Wed, Sep 12 | NMR--Chemical Shift, Equivalence, and Basic Splitting Patterns | Required: Lambert 3.1-3.6 |
| Thurs,
Sep 13 4:15-5:15 pm |
Discussion Section, Smith 121 | |
| Fri, Sep 14 |
NMR--Complex Splitting Patterns; The Karplus Equation;
Long-Range Coupling
In-Class Exercise: Resonances with Multiple Coupling Constants |
Required: Lambert 4.1, 4.3-4.10 |
| Mon, Sep 17 | Workshop 1: Analyzing 1D NMR Spectra | |
| Tues,
Sep 18 4:15-5:15 pm |
Discussion Section, Smith 121 Discussion Section Exercise: 1H NMR Multiplets with Different Coupling Constants |
|
| Wed, Sep 19 |
NMR--More Complex Splitting Patterns; Multiplets at Low Dd/J Problem Set 1 Due |
Required: T. Hoye, H. Zhao, J. Org. Chem. 2002, 67, 4014 T. Hoye, P. Hanson, J. Vyvyan, J. Org. Chem. 1994, 59, 4096 |
| Fri, Sep 21 | NMR--Chemical vs. Magnetic Inequivalence; Spin Decoupling | Required:
Lambert 4.2, 5.3, 5.5 Recommended: Claridge 4.1-4.2 |
| Mon, Sep 24 | Workshop 2: Structure Determination w/ Complex 1D NMR | |
| Tues,
Sep 25 4:15-5:15 pm |
Discussion Section, Smith 121 Discussion Section Exercise: Complex Splitting Patterns in 1H NMR |
|
| Wed, Sep 26 |
NMR--Dynamics;
Macromolecules; Chemical Shift Reagents Problem Set 2 Due |
Required: Lambert 5.1-5.2 |
| Fri, Sep 28 |
NMR--Stereochemistry
and Chiral Derivatizing Agents
In-Class Exercise: Resolving Stereochemistry with Mosher Esters |
Required: J. A. Dale, H. S. Mosher, J. Am. Chem. Soc. 1973, 95, 512. Recommended: I. Ohtani et al., J. Am. Chem. Soc. 1991, 113, 4092. |
| Mon, Oct 1 |
NMR--Nuclear Overhauser Effect; Multiple Pulse Experiments; Inversion Recovery (Measuring T1) | Required:
Lambert 5.4 Recommended: Claridge 8.1-8.6, 2.4-2.5 |
| Tues,
Oct 2 4:15-5:15 pm |
Discussion Section, Smith 121 Discussion Section Activity: Exam 1, Problem 2 from Fall 2002 |
|
|
Wed, Oct 3 Elliott N119 |
Exam 1 (Covers Sep 5-Sep 26) |
|
| Fri, Oct 5 |
No class. (8361 Only: Rescheduled to Oct 26th) |
|
| Mon, Oct 8 | NMR--Spin Echo Techniques (DEPT); 1D TOCSY | Required:
Lambert 5.6-5.8 Recommended: Claridge 4.3-4.5 |
| Tues,
Oct 9 4:15-5:15 pm |
Discussion Section, Smith 121 No scheduled activity |
|
| Wed, Oct 10 |
NMR--Two-Dimensional
NMR: COSY Techniques
Problem Set 3 Due |
Required:
Lambert 6.1 Recommended: Claridge 5.1-5.4 |
| Fri, Oct 12 |
Workshop 3: Interpreting
2D COSY Spectra
8361
Only: Lab 1 Due |
|
| Mon, Oct 15 | NMR--Two-Dimensional NMR: gCOSY, DQF-COSY, HMQC | Required:
Lambert 6.2 Recommended: Claridge 5.5-5.6, 6.1-6.3, 7.1-7.4 |
| Tues,
Oct 16 4:15-5:15 pm |
Discussion Section, Smith 121 | |
| Wed, Oct 17 |
NMR--Two-Dimensional
NMR: HMBC,
INADEQUATE Problem Set 4 Due |
Required: Lambert
6.4 Recommended: Claridge 5.7-5.9, 6.4-6.6 |
| Fri, Oct 19 | Workshop 4: Heteronuclear Correlations | |
| Mon, Oct 22 |
NMR—Two-Dimensional NMR: 2D-J, 2D-TOCSY, NOESY | Required: Lambert
6.3 Recommended: Claridge 7.1-7.4 |
| Tues,
Oct 23 4:15-5:15 pm |
Discussion Section, Smith 121 | |
|
Wed, Oct 24 Elliott N119 |
Exam 2 (Covers Sep 28-Oct 15) |
|
| Fri, Oct 26 |
8361 Only: NMR Facility Tour, Kolthoff 193 | Recommended:
Claridge 3.1-3.6 |
| Mon, Oct 29 |
NMR--Two-Dimensional NMR: ROESY; IR--Techniques and Applications | Recommended: Claridge 8.7-8.10 |
| Tues,
Oct 30 4:15-5:15 pm |
Discussion Section, Smith 121 No scheduled activity |
|
| Wed, Oct 31 |
IR--Functional Groups; Raman Spectroscopy and Microscopy (Handouts from
Oct 29)
Problem Set 5 Due |
Required: Lambert 11.1-11.10, 12.1-12.19 |
| Fri, Nov 2 |
UV-vis--Basic Principles, Functional Groups;
Fluorescence Spectroscopy |
Required: Lambert 13.1-13.5, 14.1-14.11 |
| Mon, Nov 5 |
MS--Basic Principles 8361 Only: Lab 3 Due |
Required:
Lambert 7.1-7.2 Recommended: de Hoffmann 1.1-1.17 |
| Tues,
Nov 6 4:15-5:15 pm |
Discussion Section, Smith 121 No scheduled activity |
|
| Wed, Nov 7 |
MS--Ion Sources Problem Set 6 Due |
|
| Fri, Nov 9 | MS--Mass Analyzers and Detectors | Required:
Lambert 7.3-7.4 Recommended: de Hoffmann 2.1-3.2 |
| Mon, Nov 12 | MS--Exact Masses, Isotope Patterns | Required:
Lambert 9.1-9.2 Recommended: de Hoffmann 6.1-6.7 |
| Tues,
Nov 13 4:15-5:15 pm |
Discussion Section, Smith 121 Discussion Section Activity: Exam 3 from Fall 2011 |
|
|
Wed, Nov 14 Elliott N119 |
Exam 3 (Covers Oct 17-Nov 9) |
|
| Fri, Nov 16 |
8361 Only: MS Facility Tour, Kolthoff 193 | |
| Mon, Nov 19 | MS--Radical Ion Fragmentation in Electron-Ionization MS | Required:
Lambert 8.1-8.10 Recommended: de Hoffmann 7.1-7.7 Reference: McLafferty 4.1-9.12 |
| Wed, Nov 21 | MS--More Radical Ion Fragmentation | |
| Fri, Nov 23 | Holiday. | |
| Mon, Nov 25 |
Workshop 5: Fragmentation in EI-MS | |
| Tues,
Nov 26 4:15-5:15 pm |
Discussion Section, Smith 121 | |
| Wed, Nov 28 |
MS--Even-Electron Ion Fragmentation; Tandem Mass Spectrometry In-Class Exercise: Collision-Induced Dissociation with Even-Electron Ions |
Required:
Lambert 8.11 Recommended: de Hoffmann 4.1-5.3 |
| Fri, Nov 30 |
Workshop 6: MS Analysis with Even-Electron Ions | |
| Mon, Dec 3 |
MS--Mass Spectrometry of Macromolecules and Noncovalent Complexes; Ion Mobility Spectroscopy | Required:
Lambert 9.4 Recommended: de Hoffmann 8.1-8.6 |
| Tues,
Dec 4 4:15-5:15 pm |
Discussion Section, Smith 121 | |
| Wed, Dec 5 |
Problem Set 7 Due (Can also be turned in Monday, Dec. 3) | |
| Fri, Dec 7 | ||
|
Mon, Dec 10 Elliott N119 |
Exam
4 (Covers Nov 7-Dec 5) |
|
| Wed, Dec 12 | Return Exam 4, Course Evaluations | |
|
Sat,
Dec 15 (1:30 pm - 3:30 pm) Elliott N119 |
Final Exam (Comprehensive) |